Inclusion of non-canonical amino acids
Inclusion of non-canonical amino acid residues in the peptide chain.
Replacement of the counterion
As a rule, chemically synthesized peptides are salts of trifluoroacetic acid, which is toxic to the cells of living organisms. We offer the replacement of trifluoroacetate with hydrochloride, acetate and other cell-friendly counterions.
Conjugation
Attaching various labels, such as fluorescent, radioactive, or affine, to enable detection, visualization, or purification of target peptides.
Modification of C- and N-ends
These are methods of chemical or enzymatic modification of the end groups of the peptide chain, allowing them to change their biological properties and stability.
Closure of disulfide bonds
Development of intra- or intermolecular disulfide bonds to stabilize the spatial structure of peptides.
Attaching a label
Covalent binding of peptides to other molecules, for example, proteins, carbohydrates or synthetic polymers, in order to change pharmacokinetics, improve solubility or targeted delivery.
Synthesis of «complex» peptides
Development of methods for obtaining polypeptide sequences containing non-standard amino acid residues, cyclic structures, and extended hydrophobic sites.